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pentobarbital will minimize the level or result of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unidentified.pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can minimize panobinostat degrees by ~70% and cause tre